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Genetic Research: Humanity’s Origins Nearly Extinct

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No put in the world has gotten away from the impact of Homo sapiens, from the rainforests cleared for homesteads to microplastic-bound profound seas to environment modified fly streams. Last November, the total populace arrived at eight billion.

In any case, as ubiquitous as people might be today, a group of researchers presently guarantees that our species came exceptionally near never showing up.

Scientists in China have found proof recommending that a long time back, the precursors of present day people experienced a gigantic populace crash. They highlight a radical change to the environment that happened around that time as the reason.

During a time that is known as a bottleneck, our ancestors remained at a low number, with fewer than 1,280 breeding individuals. It went on for north of 100,000 years before the populace bounced back.

“About 98.7 percent of human ancestors were lost at the beginning of the bottleneck, thus threatening our ancestors with extinction,” the scientists wrote. Their study was published on Thursday in the journal Science.

Assuming the exploration holds up, it will have provocative ramifications. It raises the possibility that early humans were split into two evolutionary lineages, one of which eventually led to Neanderthals and the other to modern humans, by a climate-driven bottleneck.

However, experts from the outside indicated that they were sceptical of the novel statistical techniques that the study’s authors employed. Stephan Schiffels, a population geneticist at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, compared it to “It is a bit like inferring the size of a stone that falls into the middle of the large lake from only the ripples that arrive at the shore some minutes later,”

Throughout recent decades, researchers have reproduced the historical backdrop of our species by examining the qualities of living individuals. The investigations all exploit similar essential realities of our science: There are dozens of new genetic mutations present in every newborn, and some of these mutations can be passed down through generations of thousands or even millions of years.

By contrasting hereditary varieties in DNA, researchers can follow individuals’ heritage to antiquated populaces that lived in various regions of the planet, moved around and interbred. They are even able to deduce the size of those populations at various points in time.

These investigations have gotten more complex as DNA sequencing innovation has developed all the more impressive. Today, researchers can analyze the whole genomes of individuals from various populaces.

Each human genome contains north of three billion hereditary letters of DNA, every one of which has been passed down for thousands or millions of years — making a huge record of our set of experiences. To peruse that set of experiences, specialists currently utilize progressively strong PCs that can do the immense quantities of computations expected for additional sensible models of human development.

Haipeng Li, a transformative genomics specialist at Chinese Foundation of Sciences in Shanghai, and his partners went through more than 10 years making their own strategy for reproducing development.

The specialists named the strategy FitCoal (short for Quick Minuscule Time Coalescent). FitCoal allows researchers to cut up history into fine cuts of time, permitting them to make a model of 1,000,000 years of development isolated into times of months.

Dr. Li stated, “It is a tool we created to figure out the history of different groups of living things, from humans to plants,”

At first he and his associates zeroed in on creatures like natural product flies. However, after obtaining sufficient genetic data from our own species, they compared the genomes of 3,154 individuals from 50 populations worldwide to examine human history.

The analysts investigated different models to find one that best makes sense of the present hereditary variety among people. They wound up with a situation that incorporated a close termination occasion among our precursors quite a while back.

“We realized we had discovered something big about human history,” said Wangjie Hu, a computational biologist at the Icahn School of Medicine at Mount Sinai in New York and an author of the study.

Before the bottleneck, the researchers finished up, the number of inhabitants in our progenitors included around 98,000 rearing people. It then shrank to less than 1,280 and remained that little for a long time. The population then returned.

In their paper, Dr. Hu and his colleagues argue that this bottleneck matches the fossil record of our ancestors.

Our part of the transformative tree split from that of different primates around quite a while back in Africa. Our progenitors had developed to be tall and enormous brained in Africa by around a long time back. Subsequently, a portion of those early people spread out to Europe and Asia, developing into Neanderthals and their cousins, the Denisovans.

Our own genealogy kept on advancing into present day people in Africa.

Following quite a while of fossil hunting, the record of old human family members remains moderately scant in Africa in the period somewhere in the range of a long time back. The new review offers an expected clarification: there simply weren’t an adequate number of individuals to abandon many remaining parts, Dr. Hu said.

Brenna Henn, a geneticist at the College of California, Davis, who was not engaged with the new review, said that a bottleneck was “one conceivable translation.” In any case, the present hereditary variety could have been delivered by an alternate transformative history, she added.

For instance, people could have veered into discrete populaces then, at that point, meet up once more. ” It would be all the more impressive to test elective models,” Dr. Henn said.

Dr. Hu and his partners recommend that a worldwide environment shift created the populace crash quite a while back. They highlight land proof that the planet became colder and drier close to the hour of their proposed bottleneck. Those conditions might have made it harder for our human precursors to track down food.

In any case, Scratch Ashton, a classicist at the English Gallery, noticed that various remaining parts of old human family members dating to the hour of the bottleneck have been tracked down external Africa.

On the off chance that an overall calamity made the human populace in Africa breakdown, he said, then, at that point, it ought to have made human family members more extraordinary somewhere else on the planet.

“The number of sites in Africa and Eurasia that date to this period suggests that it only affected a limited population, who may have been ancestors of modern humans,” he said.

Dr. Li and his partners additionally caused to notice the way that advanced people seem to have parted from Neanderthals and Denisovans after their proposed populace crash. They estimate that the two occasions are connected.

The majority of apes have 24 pairs of chromosomes, according to the researchers. People have just 23, because of the combination of two sets. The researchers speculate that a fusion of chromosomes may have emerged following the crash and spread throughout the small population.

“All humans with 24 pairs of chromosomes became extinct, while only the small isolated population with 23 pairs of chromosomes fortunately survived and passed down from generation to generation,” said Ziqian Hao, a bioinformatics researcher at Shandong First Medical University and an author of the study.

However, Dr. Schiffels is not yet sold on the story of the bottleneck: The finding is exceptionally astonishing without a doubt, and I figure the seriously amazing the case, the better the proof ought to be.”

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Boeing Starliner crews will have an extended stay on the ISS due to SpaceX’s delay

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NASA said on Tuesday that it has decided to postpone the launch until at least late March because SpaceX’s upcoming crew rotation mission to the ISS would utilize a new Dragon spacecraft that won’t be ready by the initial February launch date.

For the two NASA astronauts who traveled to the ISS last June on Boeing’s troubled Starliner spacecraft, that means an even longer stay. On June 5, they took off from Cape Canaveral, Florida, aboard a United Launch Alliance Atlas V on the first crewed mission of Starliner. They arrived at the ISS one day later for a stay that was only expected to last eight days.

NASA decided to be cautious and maintain Butch Wilmore and Suni Williams aboard the ISS while sending Starliner home without a crew due to issues with the spacecraft’s thrusters and helium leaks on its propulsion module.

In order for Williams and Wilmore to have a trip home, they will now be traveling on the SpaceX Crew Dragon Freedom, which traveled up to the ISS and docked in September, although with only two crew members on board rather than the customary four.

When Crew-10 arrived in late February, the mission’s goal was to take a trip home.

However, NASA confirmed that Crew-10 will not fly with its replacement crew until late March. This allows NASA and SpaceX time to prepare the new Dragon spacecraft, which has not yet been given a name, for the voyage. Early January is when it is anticipated to reach Florida.

“Fabrication, assembly, testing, and final integration of a new spacecraft is a painstaking endeavor that requires great attention to detail,” stated Steve Stich, the program manager for NASA’s Commercial Crew. “We appreciate the hard work by the SpaceX team to expand the Dragon fleet in support of our missions and the flexibility of the station program and expedition crews as we work together to complete the new capsule’s readiness for flight.”

It would be the fifth Dragon spacecraft with a crew. Its fleet of four current Dragon spacecraft has flown 15 times, sending 56 passengers to space, including two who were two-time fliers. The first crewed trip took place in May 2020. Each spacecraft’s name is chosen by the crew on its first flight.

According to NASA, teams considered using the other crew Dragon spacecraft that were available but decided that rescheduling Crew-10’s launch date was the best course of action.

JAXA (Japan Aerospace Exploration Agency) astronaut and mission specialist Takuya Onishi will undertake his second spaceflight, Roscosmos cosmonaut and mission specialist Kirill Peskov will make his first spaceflight, NASA astronaut and commander Anne McClain will make her second spaceflight, and NASA astronaut and pilot Nichole Ayers will become the first member of the 2021 astronaut candidate class to reach space.

Given that Crew-9 won’t be able to return home until a handover period following Crew-10’s arrival, Wilmore and Williams may have to spend nearly nine months aboard as a result of the delay.

Rotations aboard the ISS typically last six months.

It is unclear when and how Starliner will receive its final certification so that it can start trading off the regular ferry service with SpaceX, as NASA’s Commercial Crew Program aims to have two providers for U.S.-based rotation missions with SpaceX and Boeing. This is due to the Crew Flight Test mission’s incomplete launch.

According to the terms of its contract, Boeing must deliver six missions to the ISS before the space station’s service ends, which is presently scheduled for 2030.

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Ancient DNA Reveals When Humans and Neanderthals Interbred

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Neanderthals and humans likely mixed and mingled during a narrow time frame 45,000 years ago, scientists reported Thursday.

Researchers analyzed ancient genes to pinpoint the time period, which is slightly more recent than previous estimates for the mating.

Modern humans emerged in Africa hundreds of thousands of years ago and eventually spread to Europe, Asia, and beyond. Somewhere along the way, they met and mated with Neanderthals, leaving a lasting fingerprint on our genetic code.

Scientists don’t know exactly when or how the two groups entangled. But ancient bone fragments and genes are helping scientists figure that out.

“Genetic data from these samples really helps us paint a picture in more and more detail,” said study co-author Priya Moorjani at the University of California, Berkeley.

The research was published Thursday in the journals Science and Nature.

To pin down the timeline, researchers peeked at some of the oldest human genes from the skull of a woman, called Zlatý kůň or Golden Horse, named after a hill in the Czech Republic where it was found. They also examined bone fragments from an early human population in Ranis, Germany, about 140 miles (230 kilometers) away. They found snippets of Neanderthal DNA that placed the mating at around 45,000 years ago.

In a separate study, researchers tracked signs of Neanderthal DNA in our genetic code over 50,000 years. They found Neanderthal genes related to immunity and metabolism that may have helped early humans survive and thrive outside of Africa.

We still carry Neanderthals’ legacy in our DNA. Modern-day genetic quirks linked to skin color, hair color, and even nose shape can be traced back to our extinct former neighbors. And our genetic code also contains echoes from another group of extinct human cousins called Denisovans.

Future genetic studies can help scientists detangle exactly what—and who—we’re made of, said Rick Potts, director of the Smithsonian’s Human Origins program, who was not involved with the new research.

“Out of many really compelling areas of scientific investigation, one of them is: well, who are we?” Potts said.

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NASA postpones the next Artemis flights much more

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NASA has postponed the first crewed landing of the program until mid-2027, delaying the following two Artemis trips to the moon.

After identifying the primary cause of Orion heat shield erosion on the Artemis 1 mission two years ago, NASA leadership announced at a news conference on December 5 that they were postponing the Artemis 2 and 3 flights.

Artemis 2, which was originally planned to launch in September 2025, would now debut in April 2026 under the updated schedule. It will be the first crewed voyage of Orion to take four astronauts from the United States and Canada around the moon.

As a result, Artemis 3, which will use SpaceX’s Starship vehicle for the first crewed landing of the entire exploration effort, will be delayed. Originally scheduled for September 2026, that mission is now anticipated to occur in mid-2027.

Following an examination of Artemis 1’s heat shield deterioration, NASA changed that timeline. In October, agency representatives claimed to have identified the cause of the heat shield material’s release, but they did not elaborate on the cause or NASA’s plans to fix it.

NASA Deputy Administrator Pam Melroy said the issue was related to Orion’s “skip” reentry, in which the capsule enters and exits the atmosphere to release energy. In the outer layers of the heat shield, more heat was retained than anticipated, resulting in trapped gases. “This caused internal pressure to build up and led to cracking and uneven shedding of that outer layer,”  she said.

This judgment was confirmed by an independent review panel after a thorough study. “There were a lot of links in the error chain that accumulated over time that led to our inability to predict this in ground tests,” stated Amit Kshatriya, deputy assistant administrator of NASA’s Moon to Mars Program Office. This included modifications to the shape of the material blocks and modifications to the manufacturing process of the heat shield material, known as Avcoat.

He said that in areas of the Avcoat material with the required greater permeability to let the gasses out, that was verified. “In those places, we did not witness in-flight cracking, and that was the key clue for us.”

NASA will alter the reentry profile, including shortening the skip phase of the reentry, rather than replacing the entire heat shield for the Artemis 2 mission. According to ground tests, those adjustments should be enough to prevent material from breaking off as a result of cracking.

The agency has been working on a number of other Orion issues while looking into the heat shield issue, such as a battery issue that was reported in January but was reportedly fixed, according to Kshatriya.

Despite an upcoming presidential transition that would probably rethink the entire Artemis design, agency chiefs said they made the decision immediately to prevent future delays. “We’re on a day-for-day slip. We had to make this decision,” Melroy stated. “If you’re waiting for a new admininstrator to be confirmed and a team to come up to speed on all this technical work we’ve all been tracking very closely, I think that would be actually far worse.”

Shortly after President-elect Donald Trump stated on December 4 that he would select Jared Isaacman to oversee the agency, NASA Administrator Bill Nelson claimed he spoke with Isaacman. He did, however, add that he and other authorities had a discussion prior to the meetings in which they confirmed the revised plan for Artemis 2 and 3. Melroy went on to say that NASA could have been consulted on the decision, but the incoming administration has not dispatched a transition team there.

Nelson, however, maintained that the present architecture was still the most effective way to send humans back to the moon in spite of the problems and delays, pointing out that even with the most recent postponement, NASA would still make a lunar landing before China’s projected 2030 lunar mission.

“Are they going to axe Artemis and insert Starship?” In reference to the impending Trump administration, Nelson stated. Only Orion is rated for human spaceflight outside of Earth’s orbit, he said. “I expect that this is going to continue.”

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