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New exploration points to vagus nerve harm as justification for long COVID

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The review recommended that SARS-CoV-2 intervened vagus nerve brokenness (VND) could be answerable for long COVID.

New exploration to be introduced at the current year’s European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2022, Lisbon, 23-26 April) proposes that large numbers of the manifestations associated with post-COVID condition (PCC, otherwise called long COVID) could be connected with the impact of the infection on the vagus nerve – one of the most significant multi-useful nerves in the body. The review is by Dr Gemma Lladós and Dr Lourdes Mateu, University Hospital Germans Trias I Pujol, Badalona, Spain, and associates.

Numerous indications of Post-COVID-19 condition could be brought about by enduring harm supported to one of the main nerves in the human body during introductory contamination with Covid, new examination has recommended.

The vagus nerve reaches out starting from the brain into the middle and into the heart, lungs and digestive organs, as well as a few muscles incorporating those associated with gulping. All things considered, this nerve is liable for a wide assortment of normalphysical processes including controlling pulse, discourse, the gag reflex, moving food from the mouth to the stomach, moving food through the digestive organs, perspiring, and numerous others.

The vagus nerve is the tenth cranial nerve and is the longest and generally complex of every one of them. It runs from the mind all through the sum of the face and chest, arriving at the mid-region. The vagus nerve fills in as the fundamental association between the mind and the gastrointestinal lot, sending back data about the condition of the inward organs.

Long COVID is a possibly impairing disorder influencing an expected 10-15% of subjects who endure COVID-19. The creators suggest that SARS-CoV-2-interceded vagus nerve brokenness (VND) could clarify some lengthy COVID indications, including dysphonia (industrious voice issues), dysphagia (trouble in gulping), tipsiness, tachycardia (unusually high pulse), orthostatic hypotension (low circulatory strain) and looseness of the bowels.

As well as being essential to the gastrointestinal framework as it controls the exchange of food from the mouth to the stomach and moves food through the digestive organs, the vagus nerve is likewise liable for a long time cycles, for example, controlling the pulse, sweat creation and the gag reflex, as well as specific muscle developments in the mouth, including those fundamental for discourse.

The creators played out a pilot, broad morphological and useful assessment of the vagus nerve, involving imaging and useful tests in an imminent observational accomplice of long COVID subjects with indications reminiscent of VND. In their complete companion of 348 patients, 228 (66%) had somewhere around one side effect reminiscent of VND. The current assessment was acted in the initial 22 subjects with VND manifestations (10% of the aggregate) found in the Long COVID Clinic of University Hospital Germans Trias I Pujol among March and June 2021. The review is progressing, and keeps on enrolling patients.

New examination set to be introduced at the current year’s European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) researches the association between Post-COVID-19 disorder, otherwise called long COVID, and the vagus nerve.

Of the 22 subjects dissected, 20 (91%) were ladies with a middle age of 44 years. The most successive VND-related manifestations were: the runs (73%), tachycardia (59%), tipsiness, dysphagia and dysphonia (45% each), and orthostatic hypotension (14%). Practically every one of the (19 subjects, 86%) had something like 3 VND-related side effects. The middle earlier term of indications was 14 months. Six of 22 patients (27%) showed adjustment of the vagus nerve in the neck shown by ultrasound – including both thickening of the nerve and expanded ‘echogenicity’ which demonstrates gentle provocative receptive changes.

A thoracic ultrasound showed straightened ‘diaphragmatic bends’ in 10 out of 22 (46%) subjects (which deciphers an abatement in diaphragmatic versatility during breathing, or all the more just unusual relaxing). A sum of 10 of 16 (63%) evaluated people showed decreased most extreme motivation pressures, showing shortcoming of breathing muscles.

The review proposes that SARS-CoV-2-interceded vagus nerve brokenness (VND) could be liable for a significant number of the indications of long COVID, including industrious voice issues, trouble gulping, wooziness, strangely high pulse (tachycardia), low circulatory strain and stomach related issues.

Eating and stomach related capacity was additionally impacted in certain patients, with 13 of 18 evaluated (72%) having a positive screen for self-saw oropharyngeal dysphagia (inconvenience gulping). An evaluation of gastric and inside work acted in 19 patients uncovered 8 (42%) had their capacity to convey food to the stomach (by means of the throat) debilitated, with 2 of these 8 (25%) announcing trouble in gulping. Gastroesophageal reflux (heartburn) was seen in 9 of 19 (47%) people; with 4 of these 9 (44%) again experiencing issues conveying food to the stomach and 3 of these 9 (33%) with hiatal hernia – which happens when the upper piece of the stomach swells through the stomach into the chest hole.

Long COVID is a condition described by persevering and persistent medical problems brought about by COVID-19 after the patient has recuperated from the underlying diseases. It can influence practically every organ in the body, as well as cause a scope of psychological wellness and sensory system issues. The absolute most normal manifestations of long COVID incorporate weariness, migraines, windedness, loss of smell and taste, and muscle shortcoming.

To additionally comprehend the peculiarity, the specialists utilized imaging and practical tests, as well as a morphological and utilitarian assessment of the vagus nerve, in an evaluation of long COVID patients introducing at least one indications of VND.

A Voice Handicap Index 30 test (a standard method for estimating voice work) was unusual in 8/17 (47%) cases, with 7 of these 8 cases (88%) enduring dysphonia.

Numerous patients likewise showed changes in stomach related capacity, with 13 of 18 surveyed (72%) additionally having a positive evaluating for oropharyngeal dysphagia, or inconvenience gulping, which can influence the stomach related cycle. Eight patients gave indications of decreased or disabled capacity to convey food to the stomach by means of the throat, with others experiencing indigestion.

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Coffee and Tea Drinking May Reduce the Risk of Some Cancers: Research

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Drinking a cup of Joe or some tea for the holidays may be a good thing!

A study reviewed in the journal of the American Cancer Society found that people who drink either tea or coffee have a slightly lower risk of head and neck cancers, though it remains unclear if the drinks themselves directly reduce the risk.

Researchers analyzed data from 14 individual studies involving over 9,500 people with head and neck cancers and over 15,000 people without, compiled by the International Head and Neck Cancer Epidemiology Consortium.

The findings showed that individuals who drank less than four cups of caffeinated coffee daily and less than a cup of tea had a 17% and 9% lower chance, respectively, of developing head or neck cancer overall.

The study also highlighted that coffee drinkers had a reduced risk of developing oral cavity and oropharyngeal cancers located in the middle part of the throat, according to Yale Medicine. Meanwhile, tea drinkers who consumed less than a cup daily showed a lower risk of hypopharyngeal cancer, which affects the bottom part of the throat, per Johns Hopkins Medicine.

“While there has been prior research on coffee and tea consumption and reduced risk of cancer, this study highlighted their varying effects with different sub-sites of head and neck cancer, including the observation that even decaffeinated coffee had some positive impact,” said Dr. Yuan-Chin Amy Lee, senior author of the study from Huntsman Cancer Institute and the University of Utah School of Medicine, as reported by The Guardian.

“Perhaps bioactive compounds other than caffeine contribute to the potential anti-cancer effect of coffee and tea,” Lee added.

However, drinking more than one cup of tea daily was linked to a higher risk of laryngeal cancer, which forms in the larynx, the part of the throat responsible for controlling the vocal cords, according to the National Cancer Institute (NCI).

The study also acknowledged limitations, as participants self-reported their findings and were not asked about the specific types of tea or coffee consumed. Additional unaccounted factors may have influenced the results as well.

“In observational studies, it is very difficult to totally eliminate confounding effects, for example, of tobacco and alcohol from the statistical analysis,” Tom Sanders, a professor emeritus of nutrition and dietetics at King’s College London, told The Guardian.

“Consequently, people who drink a lot of coffee and tea may be more likely to avoid other harmful behaviors such as drinking alcohol and using tobacco and so may be at a lower risk of these cancers for other reasons,” added Sanders, who was not involved in the study.

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How the brain makes complex judgments based on context

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We frequently face difficult choices in life that are impacted by a number of variables. The orbitofrontal cortex (OFC) and the dorsal hippocampus (DH) are two key brain regions that are essential for our capacity to adjust and make sense of these unclear situations.

According to research conducted by researchers at the University of California Santa Barbara (UCSB), these regions work together to resolve ambiguity and facilitate quick learning.

Decision-making that depends on context

The results, which were released in the journal Current Biology, offer fresh perspectives on how certain brain regions assist us in navigating situations that depend on context and modifying our behavior accordingly.

According to UCSB neuroscientist Ron Keiflin, senior author, “I would argue that that’s the foundation of cognition.” That’s what prevents us from acting like mindless machines that react to stimuli in the same way every time.

“Our ability to understand that the meaning of certain stimuli is context-dependent is what gives us flexibility; it is what allows us to act in a situation-appropriate manner.”

Decision-making context

Think about choosing whether or not to answer a ringing phone. What you say depends on a number of variables, including the time of day, who might be calling, and where you are.

The “context,” which influences your choice, is made up of several components. The interaction between the OFC and DH is what gives rise to this cognitive flexibility, according to Keiflin.

Planning, reward valuation, and decision-making are linked to the OFC, which is situated directly above the eyes, whereas memory and spatial navigation depend on the DH, which is positioned deeper in the brain.

According to Keiflin, both areas contribute to a mental representation of the causal structure of the environment, or a “cognitive map.” The brain can model outcomes, forecast outcomes, and direct behavior thanks to this map.

Despite their significance, up until now there had been no systematic testing of the precise functions of these regions in contextual disambiguation, which determines how stimuli alter meaning based on context.

Contextualizing auditory stimuli

In order to find out, the researchers created an experiment in which rats were exposed to aural cues in two distinct settings: a room with bright lighting and a chamber with no light. There was a context-dependent meaning for every sound.

For instance, one sound indicated a reward (sugar water) only when it was light, and another only when it was dark.

The rats eventually learnt to link each sound to the appropriate context, and in one situation they showed that they understood by licking the reward cup in anticipation of a treat, but not in the other.

The OFC or DH was then momentarily disabled during the task by the researchers using chemogenetics. The rats’ ability to use context to predict rewards and control their behavior was lost when the OFC was turned off.

Disabling the DH, however, had minimal effect on performance, which was unexpected considering its well-established function in memory and spatial processing.

Enhanced learning from prior knowledge

For learning new context-dependent interactions, the DH proved essential, but it appeared to be unnecessary for recalling previously learned ones.

“If I walked into an advanced math lecture, I would understand – and learn – very little. But someone more mathematically knowledgeable would be able to understand the material, which would greatly facilitate learning,” Keiflin explained.

Additionally, the rats were able to pick up new relationships far more quickly after they had created a “cognitive map” of context-dependent interactions. The duration of training decreased from more than four months to a few days.

Brain areas cooperating

By employing the same chemogenetic strategy, the researchers discovered that the rats’ capacity to use past information to discover new associations was hampered when the OFC or DH were disabled.

While the DH allowed for the quick learning of novel context-dependent relationships, the OFC was crucial for using contextual knowledge to control immediate action.

This dual role emphasizes how these brain regions assist learning and decision-making in complementary ways.

Education and neuroscience Implications

According to Keiflin, neuroscience research frequently overlooks the well-established psychological and educational theories that prior information affects learning.

Knowing how the brain leverages past information to support learning could help develop educational plans and therapies for people who struggle with learning.

The study clarifies the different functions of the DH and OFC as well. In order to acquire new relationships, the DH is more important than the OFC, which aids in behavior regulation based on contextual knowledge.

These areas work together to help the brain adjust to complicated, dynamic surroundings.

Brain’s Capacity to make Decisions based on context

The study emphasizes how crucial contextual knowledge is for managing day-to-day existence. Human cognition is based on the brain’s capacity to resolve ambiguity, whether it be while choosing whether to answer a ringing phone or when adjusting to new knowledge.

This work highlights the complex processes that facilitate learning and decision-making while also advancing our knowledge of brain function by elucidating the functions of the OFC and DH.

This information creates opportunities to investigate the potential roles that disturbances in these systems may play in disorders like anxiety or problems with decision-making.

Since this type of learning is most likely far more reflective of the human learning experience, Keiflin stated that “a better neurobiological understanding of this rapid learning and inference of context-dependent relations is critical, as this form of learning is probably much more representative of the human learning experience.” 

The results open the door for future studies on the interactions between these brain areas in challenging, real-world situations, which could have implications for mental health and education.

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Nutrition and Its Role in Preventing Chronic Diseases

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Nutrition plays a pivotal role in maintaining overall health and preventing chronic diseases. The food we consume directly impacts our body’s ability to function optimally and ward off illnesses. Chronic diseases such as heart disease, diabetes, obesity, and certain types of cancer are closely linked to dietary habits. By adopting a balanced and nutritious diet, individuals can significantly reduce their risk of developing these conditions and improve their quality of life.

Understanding Chronic Diseases and Their Dietary Links

Chronic diseases are long-term health conditions that often develop gradually and persist for years. While genetics and environmental factors contribute to their onset, lifestyle choices—especially diet—play a significant role. Some key dietary factors influencing chronic disease risk include:

  • Excessive Calorie Intake: Overeating leads to obesity, which is a major risk factor for diabetes, heart disease, and certain cancers.
  • High Saturated and Trans Fat Consumption: These fats contribute to high cholesterol levels and increase the risk of cardiovascular diseases.
  • Excessive Sugar and Refined Carbohydrates: These can lead to insulin resistance and type 2 diabetes.
  • Low Fiber Intake: Insufficient dietary fiber is linked to digestive issues, high cholesterol, and increased risk of colon cancer.
  • Inadequate Micronutrients: Deficiencies in vitamins and minerals weaken the immune system and impair bodily functions.

Key Nutritional Strategies for Preventing Chronic Diseases

  1. Adopting a Balanced Diet: A well-rounded diet that includes fruits, vegetables, whole grains, lean proteins, and healthy fats provides essential nutrients and minimizes disease risk.
  2. Increasing Fiber Intake: Consuming fiber-rich foods such as whole grains, legumes, and vegetables helps regulate blood sugar levels, lower cholesterol, and improve gut health.
  3. Limiting Sugar and Processed Foods: Reducing intake of sugary drinks, snacks, and highly processed foods can prevent weight gain and lower the risk of metabolic disorders.
  4. Choosing Healthy Fats: Incorporating unsaturated fats from sources like nuts, seeds, and olive oil supports heart health while avoiding trans fats found in fried and processed foods.
  5. Maintaining Proper Hydration: Drinking enough water supports metabolic processes and helps maintain healthy weight.
  6. Monitoring Portion Sizes: Eating appropriate portions prevents overeating and helps maintain a healthy body weight.

Evidence-Based Benefits of Proper Nutrition

  1. Reduced Risk of Heart Disease: Diets rich in omega-3 fatty acids, fiber, and antioxidants help reduce cholesterol and blood pressure.
  2. Improved Glycemic Control: Balanced meals with low glycemic index foods prevent blood sugar spikes and reduce the risk of diabetes.
  3. Weight Management: Healthy eating habits help achieve and maintain an ideal weight, minimizing the risk of obesity-related diseases.
  4. Lower Cancer Risk: Antioxidants found in fruits and vegetables combat oxidative stress, reducing the risk of certain cancers.
  5. Enhanced Longevity: Nutrient-dense diets promote overall health and increase life expectancy.

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