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What we think about long COVID and breakthrough infections

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Like large number of others, Kathleen Hipps thought she was protected from COVID-19 after she had two chances of the Moderna antibody the previous spring. So she figured she just had a mid year cold when she got the wheezes in July. However at that point she opened some Vick’s VapoRub.

“Any individual who’s always smelled Vick’s VapoRub knows how sharp of a smell it is. What’s more, I was unable to smell it. What’s more, that is the way I realized I had COVID,” says Hipps, 40, a Los Angeles legal advisor who has two youthful children.

Furthermore, adequately sure, Hipps tried positive. “I became exceptionally ill. I was exceptionally drained, extremely blocked — could scarcely get up. I was unable to work by any means. I needed to discover associates to cover my work for me. What’s more, I just spent the following week fundamentally in bed, totally disconnected from my family,” she says.

Hipps never had a temperature, however, and didn’t have awful head or body throbs. She began having a superior after outlook on seven days, tried negative and returned to telecommuting and really focusing on her family. She thought she was completely recuperated.

“What’s more, I was in my mother’s new vehicle and out of nowhere I felt consuming. What’s more, I thought there was some kind of problem with her vehicle,” she says.

Any place she moved her foot, she could in any case feel the consuming sensation. And afterward her other foot began consuming as well. It seemed like she was strolling on hot coals, she says.

“I’ve discovered that this is neuropathy, and this a typical indication of long COVID,” Hipps says.

A few patients’ indications keep going for quite a long time or months

Long COVID is an ineffectively characterized, inadequately comprehended condition that happens when COVID-19 patients’ side effects will not disappear for quite a long time or months, or new ones arise exactly when they believe they’re generally good.

Over about a month and a half after it began, Hipps actually encounters the consuming sensation consistently, just as shivering and deadness in her grasp.

At times the deadness is so awful she can’t push her child’s carriage. Her periods are truly weighty. Also, work wears her out so quick since she needs to take bunches of breaks.

“I’m truly frightened. I mean I’m truly frightened that there are things that are going on with me that I must arrangement with for the remainder of my life,” Hipps says.

Presently stress that the COVID-19 immunizations are still profoundly viable at shielding individuals from becoming truly ill or biting the dust, are still very acceptable at keeping a great many people from coming down with the infection or getting somewhat sick.

However, advancement contaminations can occur, particularly with the delta variation. Also, it’s turning out to be progressively certain that unvaccinated individuals can grow long COVID indications, even from gentle cases.

“We’ve seen that with the actual contamination in the unvaccinated people about 30% of those people keep on having these long stretch COVID side effects,” says Dr. Avindra Nath, who is concentrating long COVID at the National Institutes of Health.

So the worry is whether immunized individuals who get tainted might be in danger for long COVID as well, Nath says.

“I feel that is a decent inquiry,” he says.

Studies investigate long COVID

A little Israeli concentrate as of late gave the main proof that advancement diseases could prompt long COVID manifestations, albeit the numbers are little. Out of around 1,500 immunized medical services laborers, 39 got contaminated, and seven announced side effects that endured over about a month and a half.

Furthermore, a huge British concentrate thusly found about 5% of individuals who got contaminated — despite the fact that they were completely immunized — experienced diligent indications, albeit the investigation additionally discovered that the chances of having manifestations for 28 days or more were split by having two immunization portions.

“I believe it’s a sensible concern. Be that as it may, it’s too soon. I think we need to follow these patients. It’s very later that they’ve been perceived. So right now we don’t have that reply,” Nath says, adding that in case there is a danger, he speculates it’s likely extremely low.

Some irresistible illness specialists remain exceptionally distrustful that long COVID from advancement contaminations is a major issue.

“Pathophysiologically, it’s very improbable to make long COVID from a leap forward contamination,” says Dr. Monica Gandhi, an irresistible sickness analyst at the University of California, San Francisco.

That is on the grounds that the resistant reaction created by the antibody would keep the infection from grabbing hold in the body or setting off an unsafe eruption by the insusceptible framework, Gandhi says.

“I think it is in no way, shape or form unthinkable, however pathophysiologically it is doubtful,” she says.

Different specialists are persuaded the issue is genuine.

“Completely I can say that we have as of now been seeing a small bunch of instances of long COVID from advancement contamination,” says David Putrino, who concentrates long COVID at Mount Sinai.

“We need to act like there is a similar possibility as consistently of growing long COVID from a gentle to-asymptomatic contamination in light of the fact that once you have it you can’t unring that ringer and you’re taking a gander at months to long periods of disease,” Putrino says. Putrino is working with Akiko Iwasaki, an immunologist at Yale University, to attempt to see how advancement contaminations can prompt tireless side effects.

Iwasaki says certain individuals might encounter long COVID in light of the fact that the infection is as yet stowing away in the body. In others, it is possible that their invulnerable frameworks go overboard to the infection — an alleged immune system reaction.

“We realize that the antibody incites a hearty invulnerable reaction to rapidly clear the infection during advancement contaminations,” Iwasaki says. “Furthermore, that recommends to me that autoimmunity might be the offender there.”

Regardless of whether advancement diseases can prompt long COVID, others say there are additionally a lot of different reasons immunized individuals should keep on continuing being mindful so as to try not to contract the infection.

“By the day’s end, my greatest concern genuinely isn’t that I will get long COVID,” says Dr. Carlos del Rio, an irresistible sickness specialist at Emory University. “It’s that I will bring COVID and offer it to another person. That is to say, I have a youthful granddaughter. On the off chance that I get contaminated, I could offer it to her. I’m more worried that individuals who are immunized can get contaminated and send to other people.”

As far as it matters for her, Hipps trusts her indications don’t torment her for quite a long time or even a long time.

“It’s unnerving on the grounds that there’s clearly a ton of things we don’t think about this infection and I’m frightened with regards to these drawn out suggestions on my body.”

In any case, she is happy she got the antibody. She realizes it likely kept her out of the clinic and kept her alive.

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Coffee and Tea Drinking May Reduce the Risk of Some Cancers: Research

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Drinking a cup of Joe or some tea for the holidays may be a good thing!

A study reviewed in the journal of the American Cancer Society found that people who drink either tea or coffee have a slightly lower risk of head and neck cancers, though it remains unclear if the drinks themselves directly reduce the risk.

Researchers analyzed data from 14 individual studies involving over 9,500 people with head and neck cancers and over 15,000 people without, compiled by the International Head and Neck Cancer Epidemiology Consortium.

The findings showed that individuals who drank less than four cups of caffeinated coffee daily and less than a cup of tea had a 17% and 9% lower chance, respectively, of developing head or neck cancer overall.

The study also highlighted that coffee drinkers had a reduced risk of developing oral cavity and oropharyngeal cancers located in the middle part of the throat, according to Yale Medicine. Meanwhile, tea drinkers who consumed less than a cup daily showed a lower risk of hypopharyngeal cancer, which affects the bottom part of the throat, per Johns Hopkins Medicine.

“While there has been prior research on coffee and tea consumption and reduced risk of cancer, this study highlighted their varying effects with different sub-sites of head and neck cancer, including the observation that even decaffeinated coffee had some positive impact,” said Dr. Yuan-Chin Amy Lee, senior author of the study from Huntsman Cancer Institute and the University of Utah School of Medicine, as reported by The Guardian.

“Perhaps bioactive compounds other than caffeine contribute to the potential anti-cancer effect of coffee and tea,” Lee added.

However, drinking more than one cup of tea daily was linked to a higher risk of laryngeal cancer, which forms in the larynx, the part of the throat responsible for controlling the vocal cords, according to the National Cancer Institute (NCI).

The study also acknowledged limitations, as participants self-reported their findings and were not asked about the specific types of tea or coffee consumed. Additional unaccounted factors may have influenced the results as well.

“In observational studies, it is very difficult to totally eliminate confounding effects, for example, of tobacco and alcohol from the statistical analysis,” Tom Sanders, a professor emeritus of nutrition and dietetics at King’s College London, told The Guardian.

“Consequently, people who drink a lot of coffee and tea may be more likely to avoid other harmful behaviors such as drinking alcohol and using tobacco and so may be at a lower risk of these cancers for other reasons,” added Sanders, who was not involved in the study.

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How the brain makes complex judgments based on context

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We frequently face difficult choices in life that are impacted by a number of variables. The orbitofrontal cortex (OFC) and the dorsal hippocampus (DH) are two key brain regions that are essential for our capacity to adjust and make sense of these unclear situations.

According to research conducted by researchers at the University of California Santa Barbara (UCSB), these regions work together to resolve ambiguity and facilitate quick learning.

Decision-making that depends on context

The results, which were released in the journal Current Biology, offer fresh perspectives on how certain brain regions assist us in navigating situations that depend on context and modifying our behavior accordingly.

According to UCSB neuroscientist Ron Keiflin, senior author, “I would argue that that’s the foundation of cognition.” That’s what prevents us from acting like mindless machines that react to stimuli in the same way every time.

“Our ability to understand that the meaning of certain stimuli is context-dependent is what gives us flexibility; it is what allows us to act in a situation-appropriate manner.”

Decision-making context

Think about choosing whether or not to answer a ringing phone. What you say depends on a number of variables, including the time of day, who might be calling, and where you are.

The “context,” which influences your choice, is made up of several components. The interaction between the OFC and DH is what gives rise to this cognitive flexibility, according to Keiflin.

Planning, reward valuation, and decision-making are linked to the OFC, which is situated directly above the eyes, whereas memory and spatial navigation depend on the DH, which is positioned deeper in the brain.

According to Keiflin, both areas contribute to a mental representation of the causal structure of the environment, or a “cognitive map.” The brain can model outcomes, forecast outcomes, and direct behavior thanks to this map.

Despite their significance, up until now there had been no systematic testing of the precise functions of these regions in contextual disambiguation, which determines how stimuli alter meaning based on context.

Contextualizing auditory stimuli

In order to find out, the researchers created an experiment in which rats were exposed to aural cues in two distinct settings: a room with bright lighting and a chamber with no light. There was a context-dependent meaning for every sound.

For instance, one sound indicated a reward (sugar water) only when it was light, and another only when it was dark.

The rats eventually learnt to link each sound to the appropriate context, and in one situation they showed that they understood by licking the reward cup in anticipation of a treat, but not in the other.

The OFC or DH was then momentarily disabled during the task by the researchers using chemogenetics. The rats’ ability to use context to predict rewards and control their behavior was lost when the OFC was turned off.

Disabling the DH, however, had minimal effect on performance, which was unexpected considering its well-established function in memory and spatial processing.

Enhanced learning from prior knowledge

For learning new context-dependent interactions, the DH proved essential, but it appeared to be unnecessary for recalling previously learned ones.

“If I walked into an advanced math lecture, I would understand – and learn – very little. But someone more mathematically knowledgeable would be able to understand the material, which would greatly facilitate learning,” Keiflin explained.

Additionally, the rats were able to pick up new relationships far more quickly after they had created a “cognitive map” of context-dependent interactions. The duration of training decreased from more than four months to a few days.

Brain areas cooperating

By employing the same chemogenetic strategy, the researchers discovered that the rats’ capacity to use past information to discover new associations was hampered when the OFC or DH were disabled.

While the DH allowed for the quick learning of novel context-dependent relationships, the OFC was crucial for using contextual knowledge to control immediate action.

This dual role emphasizes how these brain regions assist learning and decision-making in complementary ways.

Education and neuroscience Implications

According to Keiflin, neuroscience research frequently overlooks the well-established psychological and educational theories that prior information affects learning.

Knowing how the brain leverages past information to support learning could help develop educational plans and therapies for people who struggle with learning.

The study clarifies the different functions of the DH and OFC as well. In order to acquire new relationships, the DH is more important than the OFC, which aids in behavior regulation based on contextual knowledge.

These areas work together to help the brain adjust to complicated, dynamic surroundings.

Brain’s Capacity to make Decisions based on context

The study emphasizes how crucial contextual knowledge is for managing day-to-day existence. Human cognition is based on the brain’s capacity to resolve ambiguity, whether it be while choosing whether to answer a ringing phone or when adjusting to new knowledge.

This work highlights the complex processes that facilitate learning and decision-making while also advancing our knowledge of brain function by elucidating the functions of the OFC and DH.

This information creates opportunities to investigate the potential roles that disturbances in these systems may play in disorders like anxiety or problems with decision-making.

Since this type of learning is most likely far more reflective of the human learning experience, Keiflin stated that “a better neurobiological understanding of this rapid learning and inference of context-dependent relations is critical, as this form of learning is probably much more representative of the human learning experience.” 

The results open the door for future studies on the interactions between these brain areas in challenging, real-world situations, which could have implications for mental health and education.

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Nutrition and Its Role in Preventing Chronic Diseases

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Nutrition plays a pivotal role in maintaining overall health and preventing chronic diseases. The food we consume directly impacts our body’s ability to function optimally and ward off illnesses. Chronic diseases such as heart disease, diabetes, obesity, and certain types of cancer are closely linked to dietary habits. By adopting a balanced and nutritious diet, individuals can significantly reduce their risk of developing these conditions and improve their quality of life.

Understanding Chronic Diseases and Their Dietary Links

Chronic diseases are long-term health conditions that often develop gradually and persist for years. While genetics and environmental factors contribute to their onset, lifestyle choices—especially diet—play a significant role. Some key dietary factors influencing chronic disease risk include:

  • Excessive Calorie Intake: Overeating leads to obesity, which is a major risk factor for diabetes, heart disease, and certain cancers.
  • High Saturated and Trans Fat Consumption: These fats contribute to high cholesterol levels and increase the risk of cardiovascular diseases.
  • Excessive Sugar and Refined Carbohydrates: These can lead to insulin resistance and type 2 diabetes.
  • Low Fiber Intake: Insufficient dietary fiber is linked to digestive issues, high cholesterol, and increased risk of colon cancer.
  • Inadequate Micronutrients: Deficiencies in vitamins and minerals weaken the immune system and impair bodily functions.

Key Nutritional Strategies for Preventing Chronic Diseases

  1. Adopting a Balanced Diet: A well-rounded diet that includes fruits, vegetables, whole grains, lean proteins, and healthy fats provides essential nutrients and minimizes disease risk.
  2. Increasing Fiber Intake: Consuming fiber-rich foods such as whole grains, legumes, and vegetables helps regulate blood sugar levels, lower cholesterol, and improve gut health.
  3. Limiting Sugar and Processed Foods: Reducing intake of sugary drinks, snacks, and highly processed foods can prevent weight gain and lower the risk of metabolic disorders.
  4. Choosing Healthy Fats: Incorporating unsaturated fats from sources like nuts, seeds, and olive oil supports heart health while avoiding trans fats found in fried and processed foods.
  5. Maintaining Proper Hydration: Drinking enough water supports metabolic processes and helps maintain healthy weight.
  6. Monitoring Portion Sizes: Eating appropriate portions prevents overeating and helps maintain a healthy body weight.

Evidence-Based Benefits of Proper Nutrition

  1. Reduced Risk of Heart Disease: Diets rich in omega-3 fatty acids, fiber, and antioxidants help reduce cholesterol and blood pressure.
  2. Improved Glycemic Control: Balanced meals with low glycemic index foods prevent blood sugar spikes and reduce the risk of diabetes.
  3. Weight Management: Healthy eating habits help achieve and maintain an ideal weight, minimizing the risk of obesity-related diseases.
  4. Lower Cancer Risk: Antioxidants found in fruits and vegetables combat oxidative stress, reducing the risk of certain cancers.
  5. Enhanced Longevity: Nutrient-dense diets promote overall health and increase life expectancy.

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